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Several studies suggest a strong linkages involving heavy use of cannabis and increased risk of psychosis. As a result of multiple studies, researchers regularly refer to their relation as “cannabis psychosis”.

A line graph describing Psychosis risk distribution. The graph compares Cannabis Exposure with OR.

The graph above is a meta-analysis from multiple cohort studies, depicting an estimated risk ration of psychosis by the cannabis exposure, produced by other original studies.

While mechanisms of CBD and THC have been discussed, the onset of psychosis in relation to cannabis is still unknown. The majority of research is based on the assumption that the onset of psychosis follows a linear increase with increased cannabis use.

A bar graph describing Mean age (yrs) of onset of psychosis by history of cannabis and gender. The graph shows younger ages in onset of psychosis in both men and women who used cannabis.


The contents of this graph suggests a relation between the age/gender of individual with their history of using cannabis and the onset of psychosis.

Research has also brought our attention to a person’s age and gender, in relation to cannabis use to generate a trend for the onset of psychosis. In the graph below, it evident that subjects who used cannabis have a significantly higher chance of presenting their first episode of psychosis at a younger age.