The legalization of cannabis has caused a huge spike in research to further contribute to our understanding of its influence on psychosis. It’s an ongoing discovery of more knowledge to increase our safety and awareness of the plant.
Feel free to explore our news page to find the newest discoveries in the world of cannabis!
NHS opens its first clinic to treat cannabis psychosis
Date: July 1, 2019
From:The Times (London, England)
Publisher: NI Syndication Limited
Byline: Harry Shukman
The NHS has opened its first clinic for cannabis psychosis amid an “urgent” need to treat young people affected by the drug.
The clinic in Lambeth, south London, has been set up by academics whose research has found links between the mental health problem and a super-strong, readily available variety of cannabis known as skunk. Dr Marta Di Forti, of King’s College London, is running a 12-month trial with 20 patients.
She told The Times: “We do know that continuing to use cannabis after the onset of your psychosis is associated with poor clinical and functional outcomes. There are 30 per cent of people who come to the attention of psychosis services for whom cannabis was either their most important factor for the onset of psychosis or the one factor they could have prevented.”
Studies on cannabis have found that those who smoke the strongest forms every day are five times as likely to develop psychosis, a mental health problem involving hallucinations and delusion. The clinic, based at the South London and Maudsley NHS foundation trust, offers a three-month programme of cognitive behavioural therapy, motivational sessions and antipsychotic medication.
Other consultants on the project are Professor Ann McNeill, an expert on smoking and tobacco, and Professor Sir Robin Murray, the first British academic to prove a link between cannabis and psychosis. Professor Murray said: “The basic problem is we have lots of young people who have cannabis-induced psychosis. They are dependent on cannabis and they’re also psychotic, so if they go to addiction services, they get told to get lost. If they go to psychotic services, their psychosis gets treated but nobody pays much attention to their cannabis use.”
Dr Adrian James, registrar of the Royal College of Psychiatrists, said: “We welcome evidence-based improvements to mental health services.”
Copyright: COPYRIGHT 2019 NI Syndication Limited.
The Timeshttp://www.thetimes.co.uk
CITATION:
“NHS opens its first clinic to treat cannabis psychosis.” Times [London, England], 1 July 2019, p. 19. Gale Academic Onefile, https://link.gale.com/apps/doc/A591715400/AONE?u=guel77241&sid=AONE&xid=5153326b. Accessed 26 Nov. 2019.
Cannabis during pregnancy bumps psychosis risk in offspring
Date: Mar. 27, 2019 Publisher: States News Service
ST. LOUIS, MO — The following information was released by Washington University in St. Louis:
With marijuana use rising among pregnant women, new study raises concerns
By: Gerry Everding
Pregnant women who use cannabis may slightly increase the risk their unborn child will develop psychosis later in life, suggests new research from Washington University in St. Louis.
Fine
“Our research shows that prenatal marijuana exposure after maternal knowledge of pregnancy is associated with a small increase in psychosis proneness during middle childhood or about age 10,” said Jeremy Fine, an undergraduate majoring in psychological and brain sciences in Arts and Sciences at Washington University and the study’s lead author.
The findings come on the heels of several national studies documenting a dramatic increase in marijuana usage by pregnant women, including a 2018 study from Washington University School of Medicine in St. Louis that found past-month marijuana use among pregnant mothers in the United States increased by 75 percent between 2002 (2.85 percent) and 2016 (4.98 percent).
As more states legalize medicinal and recreational use of cannabis, other reports suggest that many marijuana dispensaries commonly suggest cannabis as a natural cure for pregnancy related nausea.
This latest study, published March 27 in the journal JAMA Psychiatry, suggests that pregnant women should be discouraged from using cannabis at any time in their pregnancy because so little is yet known about its health effects.
But its findings also raise new concerns that prenatal exposure to cannabis may pose a greater risk after the fetal brain begins to develop a receptor system for endocannabinoids, which are part of the naturally occurring neurotransmitter network through which cannabis affects the brain.
Bogdan
“One possible explanation for the finding of increased psychosis risk for marijuana use following, but not before, knowledge of pregnancy is that the endocannabinoid receptor system may not be in place during the early weeks of pregnancy,” said Ryan Bogdan, associate professor of psychological and brain sciences and senior author of the paper. “Prenatal cannabis exposure may be associated with later psychosis proneness in offspring only when there is sufficient fetal endocannabinoid type 1 receptor expression, which may not occur until after many mothers learn they are pregnant.”
Bogdan, who directs the Washington University BRAIN Lab where the research took place, said these latest findings build on other basic research suggesting that endocannabinoid signaling may contribute to processes, such as neurogenesis and neural migration, that play important roles in early development of brain structure and connections.
“This study raises the intriguing possibility there may be developmental windows during which cannabis exposure may be more likely to increase psychosis risk,” he said.
Tetrahydrocannabinol (THC), which is the principal psychoactive component of marijuana, mimics our body’s endocannabinoids and binds to endocannabinoid receptors to exert its effects. Various studies have confirmed that THC crosses the placental barrier to gain access to the developing fetus.
“Data from rodent studies suggest that the endocannabinoid type 1 receptor, through which the psychoactive effects of THC largely arise, is not expressed until the equivalent of 5-6 weeks of human gestation,” Fine said. “Given that mothers in our study on average learned of their pregnancy at 7.7 weeks, it is plausible that any impact of THC on psychosis risk would not arise until sufficient endocannabinoid type 1 receptors are expressed.”
After alcohol, cannabis is the second-most widely used recreational drug in developed nations. In the United States, 45 percent of adults report using cannabis at some point in their lives, with 12 percent using in the past 12 months, according to federal estimates.
The BRAIN Lab findings are based on data from the Adolescent Brain Cognitive Development (ABCD) study, an ongoing longitudinal study of child health and brain development with data collection sites throughout the nation. They used data from the initial ABCD baseline data release which included survey responses from 3,774 mothers about marijuana usage during 3,926 pregnancies. Risk of psychosis in the 4,361 children born from these pregnancies between 2005 and 2008 was measured using a questionnaire administered to the children between ages 8.9 and 11 years.
Among the 4,361 children sampled in this study, 201 (4.61 percent) were reported to have been exposed to marijuana before birth; of these 63 were exposed following maternal knowledge of pregnancy.
Bogdan and his co-authors acknowledge that the study has many limitations, including the small sample of prenatal cannabisexposed offspring; potential maternal underreporting of use during pregnancy; imprecise data on timing, amount, frequency and potency of cannabis exposure; absence of data on whether childhood psychosis proneness is associated with conversion to psychosis; and lack of data on some potential confounders, such as maternal stress and genetic risk of psychosis among parents.
Moreau
“Our research is correlational and as such cannot draw causal conclusions,” said Allison Moreau, study co-author and a graduate student in psychology at Washington University. “However, that the relationship between prenatal marijuana exposure following maternal knowledge of pregnancy was associated with offspring psychosis proneness after accounting for potentially confounding variables such as maternal education, prenatal vitamin usage, prenatal alcohol and nicotine use, child substance use, and so on increases the plausibility that prenatal cannabis exposure may contribute to a small risk of increased psychosis liability in children.”
The study provides further evidence that expectant mothers should think twice before considering cannabis usage during pregnancy.
“Given increasing cannabis accessibility and potency, as well as growing public perceptions that it’s safe to use, it is critical for additional research to understand the potential adverse consequences and benefits of cannabis throughout development and how these associations may arise.” Bogdan said. “In the meantime, evidence that prenatal marijuana use is associated with a small increase in offspring psychosis proneness suggests that marijuana use during pregnancy should be discouraged until more is known.”
Other Washington University co-authors include Nicole Karcher, post-doctoral research scholar; Arpana Agrawal, professor of psychiatry; and Cynthia Rogers, MD, assistant professor of child psychiatry, all in the Department of Psychiatry in the School of Medicine; and Deanna Barch, chair of the Department of Psychological and Brain Sciences in Arts and Sciences and the Gregory B. Couch Professor of Psychiatry at the School of Medicine.Paragraph
Copyright: COPYRIGHT 2019 States News Service
CITATION:
“CANNABIS DURING PREGNANCY BUMPS PSYCHOSIS RISK IN OFFSPRING.” States News Service, 27 Mar. 2019. Gale Academic Onefile, https://link.gale.com/apps/doc/A580309228/AONE?u=guel77241&sid=AONE&xid=60f9b585. Accessed 27 Nov. 2019.
